Reversible inhibitor of JNK1, 2, and 3 5 mg

Description

6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM).1 Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM).2,3 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion.4 In addition, 6-AN causes glial neurodegeneration.5WARNING This product is not for human or veterinary use.