Product of oxidative damage to RNA 1 mg

Description

Nitric Oxide Synthase (NOS) catalyzes the biosynthesis of nitric oxide from L-arginine. Constitutively expressed NOS is found in brain (nNOS) and endothelial cells (eNOS). iNOS is a soluble enzyme found in a variety of tissues including macrophages, hepatocytes, vascular smooth muscle cells, and chondrocytes.1,2 iNOS expression is increased by a variety of factors including LPS, IFN-γ, Il-1β, and TNF-α, whereas expression is deceased by dexamethasone.3,4,5,6,7 The enzyme has been cloned from several species including mouse, rat, and human with homology of at least 80% between these species.2 The calculated molecular weight of the protein from the deduced amino acid sequence is 130,000 – 131,000.1WARNING This product is not for human or veterinary use.