One of the principle dietary lignans present in plant fiber 1 mg

Description

Two types of 15-LO have been discovered and characterized, both of which metabolize arachidonic acid (AA) to produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE). 15-LO-1 oxygenates AA at both C15 and C12,1 whereas 15-LO-2 exclusively oxygenates C15 of AA.2 Human 15-LO-2 has a molecular mass of approximately 76 kDa and exhibits approximately 40% identity to the reticulocyte 15-LO-1.2,3 Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues.4 The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation.4,5,6 Cayman Chemical’s 15-LO-2 polyclonal antibody can be used for western blot analysis for 15-LO-2 on samples of human origin. Other applications for use of this antibody have not yet been tested.WARNING This product is not for human or veterinary use.