Inhibitor of indoleamine 2,3-dioxygenase 1 mg

Description

The jasmonates are a group of plant stress hormones that naturally occur in plants following exposure to certain types of stresses, including pathogen and herbivore attacks. (±)-Jasmonic acid methyl ester is a mixture of trans (3R/7R and 3S/7S) isomers. (±)-Jasmonic acid methyl ester induces the synthesis of proteinase inhibitors in plant leaves.1 In cancer cells, it suppresses proliferation and induces apoptosis.2 More specifically, methyl jasmonate inhibits hexokinase that is bound to mitochondria.3 As hexokinase is overexpressed in cancer cells and contributes to cancer cell growth and survival, methyl jasmonate’s disruption of mitochondrial hexokinase activity selectively targets, and kills, cancer cells. (±)-Jasmonic acid methyl ester derivatives also have potential as anti-inflammatory agents.4WARNING This product is not for human or veterinary use.