Inhibitor of histone deacetylases 5 mg


≥98% pure Inhibitor of histone deacetylases 5 mg



The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis.1,2 Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death.3 In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1.3WARNING This product is not for human or veterinary use.


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