Begacestat is an inhibitor of γ-secretase that inhibits cleavage of amyloid precursor protein (APP) to amyloid-β (1-40) (Aβ40; Item No. 21617) in vitro (IC50 = 15 nM).1 It is 14-fold selective for γ-secretase over Notch-1. Begacestat (5 mg/kg) reduces brain levels of Aβ40 and Aβ42 (Item No. 20574) in the Tg2576 transgenic mouse model of Alzheimer’s disease. It also increases contextual fear conditioning freezing time, indicating reversal of contextual memory deficits, in Tg2576 mice in a dose-dependent manner.2WARNING This product is not for human or veterinary use.