Forsythoside B is phenylpropanoid glycoside that has been found in M. alysson and has diverse biological activities.1,2,3,4,5 It scavenges PTIO (Item No. 14982), ABTS (Item No. 27317), O2-, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell-free assays (IC50s = 125.5, 14, 262.6, and 8.7 μM, respectively).2 Forsythoside B (10-100 μg/ml) reduces hydrogen peroxide-induced cytotoxicity in bone marrow-derived mesenchymal stem cells (bmMSCs). It inhibits 2-aminoethoxydiphenyl borate-induced activation of transient receptor potential vanilloid 3 (TRPV3; IC50 = 6.7 μM in HEK293 cells expressing the human receptor) and reduces carvacrol-induced scratching behavior in mice.3 Forsythoside B (40 mg/kg) reduces serum levels of TNF-α, IL-6, IL-10, endotoxin, and triggering receptor expressed on myeloid cells 1 (TREM-1) and increases survival in a rat model of cecal ligation and puncture-induced sepsis.4 It also reduces infarct size and brain edema in a rat model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion.5WARNING This product is not for human or veterinary use.