For immunochemical detection of VE-cadherin 500 µl


For immunochemical detection of VE-cadherin 500 µl



Miltefosine is an inhibitor of CTP:phosphocholine cytidylyl transferase and has antimetastatic properties.1,2,3 At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively.4 The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control.4 Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood.5WARNING This product is not for human or veterinary use.


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