CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells and thereby atherosclerotic lesions.1,2,3,4 This membrane glycoprotein can internalize fatty acids which activate PPARγ and stimulate further expression of CD36.5,6 This positive feedback loop combined with the murine CD36 knock-out studies reinforces the importance of CD36 in lipid metabolism. Additionally, CD36 is needed for the phagocytosis of P. falciparum infected erythrocytes, retinal pigment epithelial cell photoreceptor fragments, and post-apoptotic monocytes and neutrophils.7,8,9,10 CD36 expression has been monitored during hematopoietic cell differentiation and may be an indicator of tumor spreading in lymphocytic leukemia.11 Positive controls include cells from adipose and heart tissue, platelets, and macrophages. Cayman Chemical’s CD36 Monoclonal Antibody (Clone JC63.1) is recommended for flow cytometry on CD36-containing cells of murine, rat, and human origin. The antibody can also be used to antagonize CD36-mediated cellular activity. Functional blocking inhibits CD36 binding of oxLDL (macrophages) and prevents foam cell formation of macrophages.WARNING This product is not for human or veterinary use.
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