Product Description

Ganglioside GD3 (Item No. 17481) is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases.1 It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM.2 Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro.3 Ganglioside GD3-deficient adult mice exhibit progressive loss of the neural stem cell (NSC) pool and impaired neurogenesis.4 Ganglioside GD3 Monoclonal Antibody can be used for ELISA and TLC immunobloting. [Matreya, LLC. Catalog No. 1977]WARNING This product is not for human or veterinary use.