For immunochemical detection of β-catenin 500 µl

Description

The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).1 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range.2 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1α system.3,4WARNING This product is not for human or veterinary use.