For immunochemical analysis of Histone H4 1 ea

Description

D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC50 = 200 nM from S. pombe,1 300 nM for CK1δ2). It is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested.2 D 4476 blocks CK1-mediated phosphorylation of FOXO1a,1 RhoB,3 and p53.4 As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-β1-induced gene expression without cytotoxicity in A498 cells.5WARNING This product is not for human or veterinary use.