For fluorescent analysis of SIRT1 inhibitors 96 wells

Description

DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 µM)1, Cdk7 (IC50 = ~20 µM)2,3, Cdk8 (IC50 = ~20 µM)3, and Cdk9 (IC50 = 3 µM).4 Through inhibition of certain CTD kinases, DRB inhibits an elongation step during RNA polymerase II transcription5,6, which can trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells.7 DRB can also inhibit HIV transcription (IC50 = ~4 µM) by targeting elongation enhanced by the HIV-encoded transactivator Tat.8WARNING This product is not for human or veterinary use.