Product Description

SZL P1-41 is an inhibitor of the Skp1-Cullin1-F-box (SCF) family protein Skp2.1 It inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity when used at a concentration of 5 μM. SZL P1-41 selectively inhibits Skp2 over Fbw7 and β-TrCP E3 ubiquitin ligase activity in HEK293T cells. It reduces survival of LNCaP and PC3 prostate cancer cells in a concentration-dependent manner via inhibition of aerobic glycolysis and induction of apoptosis. SZL P1-41 (40 and 80 mg/kg) reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models.WARNING This product is not for human or veterinary use.