A specific p38 MAPK inhibitor 1 mg

Description

PD 98059 is a noncompetitive inhibitor of the MAPK pathway.1,2 It prevents the activation of MEK by Raf or MEK kinase (a MAPKKK) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAPKK1.3 It inhibits Raf activation of MAPKK2 with an IC50 value of 50 µM.3 PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 µM in HEK293 cells).4 It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
WARNING This product is not for human or veterinary use.