A selective inhibitor of PDGF receptor kinase. 1 mg

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues.1 AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 µM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 µM).2,3,4WARNING This product is not for human or veterinary use.