A plant growth regulator 1 g

$14.00

≥95% (mixture of isomers) pure A plant growth regulator 1 g

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Description

Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1 They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3 Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis. Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism.3,4 EC50 concentrations for activation of FXR range from 13-34 μM.5,6 In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometry of 1:2.4 CDCA toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess CDCA contributes to liver and intestinal cancers.3WARNING This product is not for human or veterinary use.

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