Product Description

Streptonigrin is a phenylpyridylquinoline originally isolated from S. flocculus with diverse biological activities.1,2,3,4,5,6 Streptonigrin (2.5-12.5 μM) induces DNA cleavage by calf thymus topoisomerase II in a concentration-dependent manner.1 It induces phage production in S. typhimurium when used at concentrations ranging from 1 to 10 μg/ml.2 Streptonigrin (10 μg/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is bactericidal against E. coli in an iron-dependent manner, an effect that is blocked by the iron chelators deferoxamine (Item No. 14595) and orthophenanthroline.3 Streptonigrin (40 nM) is cytotoxic to human HT-29 colon carcinoma cells but not to BE colon carcinoma cells in which NAD(P)H:quinone oxidoreductase is not expressed.4 Streptonigrin (0.001-0.1 μg/ml) inhibits mitosis and induces chromatin breaks in human leukocytes in a concentration-dependent manner.5 In vivo, streptonigrin (0.05 mg/kg, i.p.) increases the mean survival time in rats infected with Rauscher virus.6WARNING This product is not for human or veterinary use.