Insulin-like growth factor binding protein 5 (IGFBP5) is a secreted protein that binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis.1 IGFBP5 also displays IGF-1 independent transactivational activity in the nucleus.2 Some tissues and cell types with higher levels of this protein include kidney, heart, placenta, and skeletal cells.3 Expression has also been reported in a variety of cancers, including mammary gland and neuroblastoma.1,4 Cayman’s IGFBP5 Polyclonal Antibody is directed against a synthetic peptide sequence that partially overlaps the IGFBP5 region identified as a nuclear localization signal.2 IGFBP5 (272 amino acids) has a calculated molecular weight of 30.6 kDa. Cayman’s IGFBP5 Polyclonal Antibody can be used for Western blot applications and recognizes IGFBP5 at 33 kDa from mouse and rat samples. Reported glycosylation and phosphorylation sites may explain the band migration to 33 kDa.1,5WARNING This product is not for human or veterinary use.
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