Product Description

Tanshinone I is a diterpene that has been found in S. miltiorrhiza and has diverse biological activities, including anticancer, antidiabetic, and neuroprotective properties.1,2,3,4 It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines.2 It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity when used at concentrations of 200 and 25 µM, respectively. Tanshinone I also inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells (IC50s = 10.87 and 6.1 µM, respectively) and sensitizes them to radiation.3 It reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin (Item No. 13104) and a high-fat diet.5 Tanshinone I reduces the LPS-induced expression of TNF-α, IL-1β, and IL-6 in microglia in vitro.4 It is neuroprotective in a mouse model of Parkinson’s disease induced by MPTP, preventing dopaminergic cell death in the striatum and improving motor function when administered at a dose of 10 mg/kg per day for two weeks.WARNING This product is not for human or veterinary use.