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$77.00
≥98% pure A coumarin with diverse biological activities 5 mg
Hispidulin is a flavonoid originally isolated from A. montana with diverse biological activities.1,2,3,4,5 It inhibits platelet aggregation induced by platelet-activating factor (PAF), arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), and ADP (IC50s = 20, 4, and 13 μM, respectively).1 Hispidulin inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and bone marrow-derived macrophages (BMMs).2 In vivo, hispidulin (25 μg/kg) inhibits LPS-induced bone resorption in mice. It inhibits sphingosine kinase 1 (SPHK1) and induces ceramide accumulation and apoptosis in Caki-2 renal carcinoma cells in vitro and inhibits tumor growth in a Caki-2 mouse xenograft model.3 Pretreatment with hispidulin (40 mg/kg) reduces cognitive deficits in the Morris water maze induced by sevoflurane (Item No. 23996) in aged rats.4 It also decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.5WARNING This product is not for human or veterinary use.
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