SPHK 1 catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. This reaction plays an important role in determining cell proliferation versus cell death.1,2 SPHK 1 is found in a wide variety of tissues and cell types including kidney, liver, spleen, heart, platelets, and human tumors. On a cellular level, it is found in the cytosolic and membrane fractions.3 Based on the amino acid sequence, this protein has a molecular weight of approximately 43 kDa. The observed band at 50 kDa may be explained by some reported post translational modifications.4WARNING This product is not for human or veterinary use.
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