VE-cadherin (vascular endothelium cadherin), also known as Cadherin-5, is an endothelial cell-specific adhesion molecule localized at intracellular junctions.1,2,3 The protein belongs to the cadherin superfamily of adhesion molecules.4 VE-cadherin plays a pivotal role in vascular structure assembly. Endothelial cells fail to organize in a vessel-like pattern if the VE-cadherin gene is disrupted.5 In this aspect, VE-cadherin is a critical component of a protein complex which controls endothelial cell tube formation.6 VE-cadherin is also critical for maintenance of the endothelium. Following disruption of endothelial cell monolayers with an anti-VE-cadherin antibody, endothelial cells rapidly resynthesize VE-cadherin in order to restore their intracellular junctions.7 Human VE-cadherin has a molecular mass of approximately 87,500 based on the deduced amino acid sequence and is 83% and 79% homologous to porcine and mouse VE-cadherin at the amino acid level. Cayman’s VE-Cadherin Polyclonal Antibody can be used for immunocytochemistry, immunohistochemistry, immmunoprecipitation, and Western blot applications. The antibody recognizes VE-Cadherin at 88 kDa from human, bovine, and mouse samples.WARNING This product is not for human or veterinary use.
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