A colorimetric 96-well assay for inorganic phosphate 2 x 96 wells

Description

Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.1 After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.2 Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.3 Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
WARNING This product is not for human or veterinary use.