Galactosylceramides are glycosphingolipids that contain galactose attached to a ceramide containing an N-acyl hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides, found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system.1,2 Galactosylceramides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells.1,2,3 They accumulate in globoid cells in the brain of patients with Krabbe disease, a disorder characterized by a deficiency in galactosylcerebrosidase activity.2 Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, with smaller chain lengths predominant during development and longer chain lengths predominant in mature cells.4 They accumulate in the lysosome of patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency.5,6 Sphingomyelins are bioactive sphingolipids found in mammalian cell membranes.7 They make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. Sphingolipid Mixture contains bovine hydroxy- and non-hydroxy galactosylcerebrosides, sulfatides, and sphingomyelins. It is intended for use as a reference standard for the identification of these lipids in various sample types by TLC, LC-, or GC-MS. [Matreya, LLC. Catalog No. 1128]WARNING This product is not for human or veterinary use.