An internal standard for the quantification of trametinib 1 mg

$40,700.00

≥99% deuterated forms (d1-d3) pure An internal standard for the quantification of trametinib 1 mg

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Description

Troglitazone-d4 is intended for use as an internal standard for the quantification of troglitazone (Item No. 71750) by GC- or LC-MS. Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).1 It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87%, respectively.2 It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.3WARNING This product is not for human or veterinary use.

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