An EGFR activator and inhibitor of KID-KIX interactions 5 mg

$6,900.00

≥98% pure An EGFR activator and inhibitor of KID-KIX interactions 5 mg

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Description

DMH4 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.16 µM in a cell-free assay) and a derivative of dorsomorphin (Item No. 11967).1 It selectively inhibits VEGFR2 over activin receptor-like kinase 2 (ALK2), ALK5, and AMPK (IC50s = 3.5, >30, and 8 µM, respectively, in a cell-free assay). DMH4 inhibits growth of H460 and A549 human lung cancer cells (GI50s = 13.3 and 2.8 µM, respectively) and reduces VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs; IC50 = 1 µM).1,2WARNING This product is not for human or veterinary use.

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