An anticancer taxane 5 mg

$4,900.00

≥98% pure An anticancer taxane 5 mg

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Description

8-Nitrotryptanthrin is a derivative of tryptanthrin (Item No. 17913) with diverse biological activities.1,2,3,4,5 It inhibits human recombinant indoleamine 2,3-dioxygenase 1 (IDO1; IC50 = 0.103 μM) and its enzyme activity in HEK293 cells expressing human IDO1 (IC50 = 0.18 μM).1 8-Nitrotryptanthrin inhibits the growth of U251 glioblastoma, H522 lung, M14 melanoma, DU145 prostate, and A498 renal cancer cells (GI50s = 4.5, 4.8, 15, 8, and 2 μM, respectively).2 It is active against M. tuberculosis, methicillin resistant S. aureus (MRSA), and M. furfur (MICs = 0.032, 0.5, and 5 μg/ml, respectively).3,4 8-Nitrotyrptanthrin is also active against T. brucei (EC50 = 0.24 μg/ml).5WARNING This product is not for human or veterinary use.

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