An anthracycline with anticancer activity 1 mg

$9,400.00

≥98% pure An anthracycline with anticancer activity 1 mg

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Description

LB-100 is an inhibitor of protein phosphatase 2A (PP2A) with anticancer activity.1 It reduces PP2A activity and is cytotoxic to BxPC-3 and PANC-1 cells (IC50s = 0.85 and 3.87 μM, respectively). LB-100 inhibits radiation-induced Rad51 focus formation and homologous recombination repair in PANC-1 and MiaPaCa-2 cells.2 In vivo, it increases tumor microvessel density and VEGF secretion and decreases tumor volume in a PANC-1 mouse xenograft model when administered at a dose of 2 mg/kg.1 LB-100 (1.5 mg/kg) enhances radiation-induced reductions in tumor volume in CNE1 and CNE2 radioresistant nasopharyngeal carcinoma mouse xenograft models.3WARNING This product is not for human or veterinary use.

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