A tryptanthrin derivative with diverse biological activities 1 mg

Description

Balaglitazone is a partial agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50 = 1.351 μM in a transactivation assay).1 It decreases non-fasting plasma glucose levels in diabetic db/db mice (ED90 = 3 mg/kg per day). Balaglitazone (5 and 10 mg/kg per day) decreases plasma levels of insulin and glucose in an oral glucose tolerance test in diet-induced obese rats.2 In doxorubicin-resistant K562 human myelogenous leukemia cells, balaglitazone (25 μM) decreases P-glycoprotein (P-gp) levels, increases intracellular accumulation of the P-gp substrate rhodamine 123 (Item No. 16672), and sensitizes cells to doxorubicin (Item No. 15007).3WARNING This product is not for human or veterinary use.